The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial
Authors' conclusion
Analyzing the largest multicenter cohort of patients with extensive burns, we find that burn injury is associated with chronic pain, and symptoms of anxiety and depression.
Study context
- Population
- Survivors of extensive burns (partial- or full-thickness burns requiring surgical treatment) vs general population adults478 per matched group
- Comparison
- Burn patients vs general population
- Primary endpoint
- Prevalence of long-term pain and symptoms of anxiety and depression
Methodological detailspost hoc analysis, propensity-score matched, multicentre
- Post hoc analysis
- Propensity-score matched
- Multicentre
Primary result
As reported in the abstract
Chronic pain, anxiety and depressive symptoms
- Burn patients significantly more likely to report moderate and a lot of pain
- p = 0.002
- Anxiety symptoms significantly higher in burn patients in two of four levels (most of the time; some of the time)
- p < 0.0001
- Burn patients significantly less likely to report absence of depressive symptoms
- p < 0.0001
Further findings
Mental health affecting social life
- Burn patients significantly more likely to report that mental health affects their social life
Factors associated with pain, anxiety and depressive symptoms (burns cohort, multivariable analysis)
- TBSA, history of depression and female sex independently associated with pain, anxiety and depressive symptoms
- Chronic pain and anxiety symptoms independently predicted depressive symptoms
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial. Crit Care. Published 22 March 2024. doi:10.
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