Hemodynamics, fluids & transfusion
Tranexamic Acid Administration During Liver Transplantation Is Not Associated With Lower Blood Loss or With Reduced Utilization of Red Blood Cell Transfusion
Main finding · Intraoperative blood lossResult — go to the resultRegression coefficient B −0.020 CI −0.051 to 0.012Authors' conclusion
Our data do not support the use of TXA during liver transplantation.
Study context
- Population
- Patients undergoing liver transplantation 2004–2017 at Heidelberg University Hospital, Germanytransplantations analysed
- Participants
- 779 patients
- Exposure
- Intraoperative tranexamic acid (TXA) vs no TXA during liver transplantation
- TXAn = 262
- Outcome
- Intraoperative blood loss
Methodological detailssingle-centre, multivariable linear regression
- Single-centre
- Multivariable linear regression
Main finding
As reported in the abstract
Regression coefficient B
−0.020
CI −0.051 to 0.012
P = 0.226
- Median intraoperative blood loss, all patients
- 3000 mL (1600-5500 mL)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Regression coefficient B (CI) | P value |
|---|---|---|
| Intraoperative RBC transfusion | 0.023 (−0.006 to 0.053) | P = 0.116 |
| Postoperative RBC transfusion | 0.007 (−0.032 to 0.046) | P = 0.717 |
Safety
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Thrombosis (composite of hepatic artery, portal vein and inferior vena cava thrombosis)Cox proportional hazards model | 1.110 (0.903–1.365) | P = 0.321 | |
| 0.512Hazard ratio (log scale) |
Original publication
Tranexamic Acid Administration During Liver Transplantation Is Not Associated With Lower Blood Loss or With Reduced Utilization of Red Blood Cell Transfusion. Anesth Analg. Published 16 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →