Hemodynamics, fluids & transfusion
Oral as compared to intravenous tranexamic acid to limit peri-operative blood loss associated with primary total hip arthroplasty: A randomised noninferiority trial
Primary result · Total blood loss (TBL)Result — go to the resultDifference between medians 35 ml 95% CI −103.77 to 33.77Authors' conclusion
TXA as an oral premedication before PLTHA is noninferior to its intravenous administration regarding peri-operative TBL.
Study context
- Population
- Patients scheduled for primary posterolateral approached total hip arthroplasty (PLTHA), University Hospital of Liège, Belgium, May 2021 to November 2022108 i.v., 104 oral analysed
- Participants
- 228 patients
- Comparison
- Oral vs intravenous tranexamic acid (TXA)
- Oraln = 114
- i.v.n = 114reference
- Primary endpoint
- Total blood loss (measured intra-operative and drainage blood loss)
- Follow-up
- Up to 48 h after surgery
Methodological detailsnoninferiority, single centre, double-blind
- Noninferiority
- Single centre
- Double-blind
Primary result
Total blood loss (TBL)
Difference between medians
35 ml
95% CI −103.77 to 33.77
By group
As reported in the abstract
Secondary outcomes
Evolution of total blood loss (TBL) and haemoglobin over time
- No significant interaction between group and time
Original publication
Oral as compared to intravenous tranexamic acid to limit peri-operative blood loss associated with primary total hip arthroplasty: A randomised noninferiority trial. Eur J Anaesthesiol. Published 12 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →