Tranexamic acid-associated intrathecal toxicity during spinal anaesthesia: A narrative review of 22 recent reports
Authors' conclusion
The author concludes that inadvertent intrathecal TXA is associated with mortality or permanent harm in more than 50% of patients.
Study context
- Population
- Published reports of accidental intrathecal tranexamic acid (TXA) administration, Medline and Google Scholar, July 2018 to September 2022errors reported
- Participants
- 22 participants
- Outcome
- Outcome of accidental intrathecal TXA
Methodological detailshuman factors analysis classification system (HFACS) framework
- Human factors analysis classification system (HFACS) framework
Pooled result
As reported in the abstract
Death
8
36%
Permanent harm
4
19%
Fatality rate, female vs male
6/13 vs 2/8
Refractory or super refractory status epilepticus requiring mechanical ventilation and ICU
19 of 21
Further pooled results
Surgical setting of errors
- Errors during orthopaedic surgery or lower segment caesarean section
- 15/22
- Orthopaedic surgery
- 10
- Lower segment caesarean section
- 5
Contributory factors (HFACS)
- Mistaking look-alike TXA ampoules for local anaesthetic was the predominant cause
Original publication
Tranexamic acid-associated intrathecal toxicity during spinal anaesthesia: A narrative review of 22 recent reports. Eur J Anaesthesiol. Published 6 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →