Association between perioperative neuraxial local anesthetic neurotoxicity and arachnoiditis: a narrative review of published reports
Authors' conclusion
The existing literature attributing arachnoiditis to local anesthetic neurotoxicity is largely outdated, incomplete, and/or confounded by other potential causes, and thus insufficient to characterize the features and strength of any association.
Study context
- Population
- Published reports of arachnoiditis attributed to local anesthetic neurotoxicity after perioperative neuraxial anesthesia, up to December 202238 articles
- Participants
- 130 participants
- Outcome
- Characteristics of published reports of arachnoiditis attributed to neuraxial local anesthetic neurotoxicity
Methodological detailssystematic search methodology
- Systematic search methodology
Main finding
As reported in the abstract
- Articles included
- 38
- Patients
- 130
- Articles published prior to this century (inconsistent with modern practice)
- over one-half
- Epidurals
- 78
- Spinals
- 48
- Combined spinal-epidurals
- 5
- Complicated needle/catheter insertion (paresthesia, pain or multiple attempts), irrespective of technique
- at least 57%
- Onset of neurological symptoms after neuraxial blockade
- immediate to 8 years
Original publication
Association between perioperative neuraxial local anesthetic neurotoxicity and arachnoiditis: a narrative review of published reports. Reg Anesth Pain Med. Published 30 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →