Transversus abdominis plane block in minimally invasive colon surgery: a multicenter three-arm randomized controlled superiority and non-inferiority clinical trial
Authors' conclusion
The L-TAP block was superior to placebo and non-inferior to the US-TAP block. However, neither met our predetermined estimate of the minimal clinically important difference of 10 mg morphine.
Study context
- Population
- Patients undergoing elective minimally invasive colon surgery
- Participants
- 340 patients
- Comparison
- US-TAP block and L-TAP block vs placebo; L-TAP vs US-TAP
- US-TAPn = 127
- L-TAPn = 127
- Placebon = 86reference
- Primary endpoint
- Postoperative morphine equivalent consumption
- Follow-up
- 24 hours
Methodological detailsmulticentre, three-arm, superiority and non-inferiority, placebo-controlled
- Multicentre
- Three-arm
- Superiority and non-inferiority
- Placebo-controlled
Primary result
As reported in the abstract
24-h postoperative morphine equivalent consumption
Difference, mg morphineP value
US-TAP vs Placebono different from placebo
−1.4(97.5% CI −6.8 to 4.0)
P = 0.55L-TAP vs Placebosuperior to placebo
−5.9(97.5% CI −11.3 to −0.5)
P = 0.01L-TAP vs US-TAPnon-inferior; non-inferiority margin 10 mg morphine dose equivalents
−4.5(98.75% CI −10.0 to 1.1)
Non-inferiority margin 10 as printed, not drawn
Original publication
Transversus abdominis plane block in minimally invasive colon surgery: a multicenter three-arm randomized controlled superiority and non-inferiority clinical trial. Reg Anesth Pain Med. Published 14 November 2024. doi:10.
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