Trends in clinical characteristics and outcomes of all critically ill COVID-19 adult patients hospitalized in France between March 2020 and June 2021: a national database study
An erratum to this article was published (Ann Intensive Care, 19 Mar 2023 ↗)
Authors' conclusion
In this large database of ICU patients admitted for COVID-19, we observed a decline in invasive mechanical ventilation, vasopressors, and RRT use over time but a high risk of in-hospital death. Vaccination was identified as protective against the risk of invasive mechanical ventilation and in-hospital death.
Study context
- Population
- All adults with COVID-19 hospitalised in French ICUs, March 1, 2020 to June 30, 2021
- Participants
- 105,979 adults
- Exposure
- Three COVID-19 surge periods
- Outcome
- In-hospital mortality
Methodological detailsnational database
- National database
Main finding
As reported in the abstract
Surge 1
24%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Invasive mechanical ventilation as highest level of respiratory support · whole periodSurge 1 vs Surge 3 · across the three surge periods | P < 0.001 |
Invasive mechanical ventilation as highest level of respiratory support · whole period
- Adjusted, time period associated with less invasive mechanical ventilation
Vasopressor use
- Decline in the use of vasopressors over time
Invasive mechanical ventilation, vaccinated vs not
- Vaccination against COVID-19, adjusted sub-hazard ratio (aSHR)
- 0.64 [0.53-0.76]
Intra-hospital death, vaccinated vs not
- Vaccination against COVID-19, aSHR
- 0.80, [0.68-0.95]
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →