Respiratory failure & ventilation
Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial
Primary resultResult — go to the resultRisk difference 0.7 percentage points 95% CI −0.7 to 2.0Authors' conclusion
In adult patients receiving mechanical ventilation and supplemental oxygen in the ICU, minimizing oxygen exposure through conservative oxygen therapy did not significantly reduce all-cause mortality at 90 days.
Study context
- Population
- Mechanically ventilated adults receiving supplemental oxygen in 97 UK intensive care units (ICUs)16,394 with primary outcome data
- Participants
- 16,500 participants
- Comparison
- Conservative oxygen therapy vs usual oxygen therapy
- Conservative oxygen therapyn = 8,258
- Usual oxygen therapyn = 8,242reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, pragmatic, Enrolled May 2021 to November 2024; follow-up completed February 2025
- Multicentre
- Pragmatic
- Enrolled May 2021 to November 2024; follow-up completed February 2025
Primary result
As reported in the abstract
Risk difference
0.7 percentage points
95% CI −0.7 to 2.0
P = 0.28
Events by treatment group
Conservative oxygen therapy vs Usual oxygen therapy
risk difference 0.7 percentage points (95% CI −0.7 to 2.0); P = 0.28
Secondary outcomes
Exposure to supplemental oxygen
- 29% lower with conservative vs usual oxygen therapy
ICU and hospital LOS, days alive and free from organ support at 30 days, mortality at other time points
- No significant differences
Original publication
Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial. JAMA. Published 5 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →