Cardiac arrest & resuscitation
Ultra-early short- and middle-latency SSEP accurately predict good and poor outcome after cardiac arrest
Authors' conclusion
Ultra-early quantitative assessment of short- and middle-latency SSEPs provides highly accurate prediction of both good and poor neurological outcomes after CA.
Study context
- Population
- Comatose adults after cardiac arrest, multimodal prognostic assessment within 6 h
- Participants
- 65 adults
- Comparison
- Ultra-early short- and middle-latency SSEPs vs other early prognostic indices
- Outcome
- Poor neurological outcome (Cerebral Performance Category (CPC) 3-5)
- Follow-up
- Hospital discharge
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Prediction of poor and good outcome
| Test or model | Sensitivity (poor outcome) | Sensitivity (good outcome) | Specificity (poor outcome) | Specificity (good outcome) |
|---|---|---|---|---|
| Bilaterally absent N20 | 67[48-82]% | — not stated in the abstract | 100[89-100]% | — not stated in the abstract |
| Absent N20 or low-amplitude, prolonged N20 without N70 | 93[79-99]% | — not stated in the abstract | without compromising specificity | — not stated in the abstract |
| High-amplitude N20, normal duration, preserved N70 | — not stated in the abstract | 94[79-99]% | — not stated in the abstract | 100[89-100]% |
Sensitivity (poor outcome)
Bilaterally absent N2067[48-82]%
Absent N20 or low-amplitude, prolonged N20 without N7093[79-99]%
High-amplitude N20, normal duration, preserved N70— not stated in the abstract
Sensitivity (good outcome)
Bilaterally absent N20— not stated in the abstract
Absent N20 or low-amplitude, prolonged N20 without N70— not stated in the abstract
High-amplitude N20, normal duration, preserved N7094[79-99]%
Specificity (poor outcome)
Bilaterally absent N20100[89-100]%
Absent N20 or low-amplitude, prolonged N20 without N70without compromising specificity
High-amplitude N20, normal duration, preserved N70— not stated in the abstract
Specificity (good outcome)
Bilaterally absent N20— not stated in the abstract
Absent N20 or low-amplitude, prolonged N20 without N70— not stated in the abstract
High-amplitude N20, normal duration, preserved N70100[89-100]%
— not stated in the abstract
Further findings
SSEPs vs other early prognostic indices
- SSEPs outperformed all other early prognostic indices for both good and poor outcome prediction
Concordant unfavourable predictors
- All poor outcome patients had at least two concordant unfavourable predictors
Original publication
Ultra-early short- and middle-latency SSEP accurately predict good and poor outcome after cardiac arrest. Resuscitation. Published 4 September 2025. doi:10.
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