Urinary neutrophil gelatinase-associated lipocalin and plasma IL-6 in discontinuation of continuous venovenous hemodiafiltration for severe acute kidney injury: a multicenter prospective observational study
Authors' conclusion
Urinary NGAL at CVVHDF initiation and discontinuation was associated with mortality and RRT dependence, respectively.
Study context
- Population
- Adults with severe acute kidney injury (AKI) requiring CVVHDF in intensive care unit (ICU), seven university-affiliated ICUs105 CVVHDF survivors
- Participants
- 133 adults
- Exposure
- Success vs Failure
- CVVHDF nonsurvivorsn = 28
- Successn = 70reference
- Failuren = 35
- Outcome
- Deaths during CVVHDF and CVVHDF dependence
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Urinary NGAL at CVVHDF discontinuation · CVVHDF discontinuation
P < 0.01
Observational data: associations, not effects.
Further findings
Temporal change of urinary neutrophil gelatinase-associated lipocalin (NGAL) · first 48 h since CVVHDF initiation
- Temporal elevations of urinary NGAL in CVVHDF nonsurvivors and those who failed CVVHDF discontinuation
Original publication
Urinary neutrophil gelatinase-associated lipocalin and plasma IL-6 in discontinuation of continuous venovenous hemodiafiltration for severe acute kidney injury: a multicenter prospective observational study. Ann Intensive Care. Published 15 May 2023. doi:10.
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