The furosemide stress test predicts successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury
Authors' conclusion
A urine output >188 mL in the first 2 h after FST predicted successful discontinuation of CRRT.
Study context
- Population
- Critically ill patients with AKI undergoing an initial attempt at discontinuation of continuous renal replacement therapy (CRRT)
- Participants
- 55 patients
- Comparison
- 2-h urine output after furosemide stress test (FST) vs 24-h urine output on the previous day vs urine NGAL for predicting successful CRRT discontinuation
- Outcome
- Successful discontinuation of CRRT (alive without RRT for 7 days after discontinuation)
- Follow-up
- 7 days
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Performance
As reported in the abstract
Prediction of successful CRRT discontinuation
| Test or model | AUC | Optimal cut-off | Sensitivity | Specificity |
|---|---|---|---|---|
| FST 2-h urine output | 0.913 | 188 mL | 0.800 | 0.920 |
| 24-h urine output | 0.739 | |||
| Urine NGAL | 0.725 |
AUC
FST 2-h urine output0.913
24-h urine output0.739
Urine NGAL0.725
Optimal cut-off
FST 2-h urine output188 mL
24-h urine output— not stated in the abstract
Urine NGAL— not stated in the abstract
Sensitivity
FST 2-h urine output0.800
24-h urine output— not stated in the abstract
Urine NGAL— not stated in the abstract
Specificity
FST 2-h urine output0.920
24-h urine output— not stated in the abstract
Urine NGAL— not stated in the abstract
- FST 2-h urine output vs 24-h urine output: P = 0.003 — significantly greater AUC for FST
- FST 2-h urine output vs Urine NGAL: P = 0.020 — significantly greater AUC for FST
- Successful discontinuation of CRRT
- 30 of 55
Original publication
The furosemide stress test predicts successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury. J Crit Care. Published 9 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →