Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes
Authors' conclusion
Our findings suggest AKI-SP1 is characterized by a reparative, regenerative phenotype and AKI-SP2 is characterized as an immune and inflammatory phenotype associated with blood bacteremia.
Study context
- Population
- ICU patients with sepsis from a suspected respiratory infection86 with AKI
- Participants
- 173 patients
- Exposure
- AKI-SP2 vs AKI-SP1
- AKI-SP2n = 20
- AKI-SP1n = 66reference
- Outcome
- Urinary protein abundance, AKI-SP2 vs AKI-SP1
- Follow-up
- ICU admission
Methodological detailsurinary proteomics (aptamer-based), LASSO classification
- Urinary proteomics (aptamer-based)
- LASSO classification
Main finding
As reported in the abstract
Urine proteins higher in AKI-SP2 (FDR < 0.05)
117
Urine proteins higher in AKI-SP1 (FDR < 0.05)
195
Observational data: associations, not effects.
Further findings
Risk of RRT during hospitalization
- Overlap between proteins differentiating AKI sub-phenotypes and those differentiating risk of RRT
Aptamer vs ELISA protein assays
- Variable correlation between top aptamers and ELISA
LASSO urinary proteomic model to classify AKI-SP2
- Mean AUC
- 0.86 (95% CI 0.69-0.99)
Original publication
Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes. Crit Care. Published 18 December 2024. doi:10.
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