Use of [TIMP-2] • [IGFBP7] to identify sepsis-related acute kidney injury in the emergency department
Main finding · Moderate-severe AKI within 24 hResult — go to the resultAdjusted odds ratio 1.24 95% CI 1.07–1.43Authors' conclusion
In conclusion, urinary [TIMP-2]•[IGFBP7] measured on presentation to the ED had only moderate discrimination for sepsis-associated AKI.
Study context
- Population
- Adults presenting to the Emergency Department (ED) with suspected infection and NEWS 2 ≥3
- Outcome
- Moderate-severe AKI (KDIGO definition)
- Follow-up
- Within 24 h
Methodological detailssingle-centre
- Single-centre
Main finding
Moderate-severe AKI within 24 h · 24 h
Adjusted odds ratio
1.24
95% CI 1.07–1.43
P < 0.01
Higher admission urinary [TIMP-2]•[IGFBP7]
aOR 1.24 (95% CI 1.07–1.43); P < 0.01
As reported in the abstract
- Overall discrimination, AUC (modest)
- 0.67
- NPV for excluding acute kidney injury (AKI), low values (<0.3)
- 0.86
Observational data: associations, not effects.
Further findings
Creatinine trajectories and inflammatory profiles
- Largely similar across groups, except elevated IL-10 and IL-1RN in high-risk patients
Original publication
Use of [TIMP-2] • [IGFBP7] to identify sepsis-related acute kidney injury in the emergency department. Ann Intensive Care. Published 17 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →