Regional anesthesia

Vagus nerve block as a diagnostic tool for VANCOUVER syndrome

Reg Anesth Pain MedPublished Case series

Authors' conclusion

Vagus nerve block can confirm the diagnosis and lateralize the affected nerve in patients with VANCOUVER syndrome who cannot lateralize their symptoms.

Study context

Population
Patients potentially having VANCOUVER syndrome who could not lateralize their sensory symptomseach had both sides blocked
Participants
2 participants
Exposure
Ipsilateral vs Contralateral
Outcome
Cough
Methodological detailsretrospective medical record review, ultrasound-guided, outpatient procedure, Percutaneous cervical vagus nerve block in the supine position, ultrasound-guided, in-plane needle technique; unilateral block, then contralateral block several weeks later
  • Retrospective medical record review
  • Ultrasound-guided
  • Outpatient procedure
  • Percutaneous cervical vagus nerve block in the supine position, ultrasound-guided, in-plane needle technique; unilateral block, then contralateral block several weeks later

Main finding

As reported in the abstract

  • Both patients had temporary resolution of cough after ipsilateral block, no effect after contralateral block

Observational data: associations, not effects.

Safety

Effects during vagus nerve block

Temporary vocal hoarseness and ipsilateral Horner syndrome; no hemodynamic disturbances

Original publication

Vagus nerve block as a diagnostic tool for VANCOUVER syndrome. Reg Anesth Pain Med. Published 3 February 2026. doi:10.1136/rapm-2025-107471

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