Cardiothoracic & vascular anaesthesia
Vasoplegia After Left Ventricular Assist Device Implantation: A Meta-analysis of Incidence, Predictors, and Clinical Outcomes
Authors' conclusion
Vasoplegia affects approximately one-third of patients following LVAD implantation and is associated with worse postoperative outcomes.
Study context
- Population
- Patients receiving a continuous-flow left ventricular assist device (LVAD), tertiary care
- Participants
- 1,855 patients · 9 observational studies
- Comparison
- Vasoplegia vs no vasoplegia after continuous-flow LVAD implantation
- Outcome
- Incidence of vasoplegia
Methodological detailsstudy-level, random-effects, Medline, Embase and Cochrane Library searched from inception to March 2026
- Study-level
- Random-effects
- Medline, Embase and Cochrane Library searched from inception to March 2026
Pooled result
As reported in the abstract
Pooled incidence of vasoplegia
34.2%
95% CI 26.9%–42.4%
Further pooled results
Clinical outcomes, vasoplegia vs no vasoplegia
- Vasoplegia associated with higher early mortality and major bleeding, worse long-term survival and longer hospital stays
- No difference in ICU mortality, AKI, stroke and right HF
Predictors of vasoplegia
- Male sex and higher BMI risk factors; higher BP protective
- Not significant predictors: renin-angiotensin-aldosterone inhibitors, β-blockers, neutrophil/lymphocyte ratio, INTERMACS classes I to II, CPB time, serum creatinine, diabetes, ischemic cardiomyopathy
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Vasoplegia After Left Ventricular Assist Device Implantation: A Meta-analysis of Incidence, Predictors, and Clinical Outcomes. J Cardiothorac Vasc Anesth. Published 24 August 2026. doi:10.
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