Cardiothoracic & vascular anesthesia
Vasoplegia in Cardiac Surgery: A Systematic Review and Meta-analysis of Current Definitions and Their Influence on Clinical Outcomes
Authors' conclusion
The large variability in vasoplegia definitions is associated with significant heterogeneity regarding incidence and clinical outcomes, which cannot be explained by factors included in our models.
Study context
- Population
- Cardiac surgery patients on CPB, studies defining vasoplegia, 1977 to 2023100 studies reviewed
- Comparison
- Vasoplegia definitions (mean arterial pressure (MAP) thresholds) and their influence on reported incidence, intensive care unit (ICU) length of stay (LOS) and 30-day mortality
- Outcome
- Vasoplegia incidence
Methodological detailsrandom intercept logistic regression, random effect meta-analysis, meta-regression
- Random intercept logistic regression
- Random effect meta-analysis
- Meta-regression
Pooled result
As reported in the abstract
Mean incidence (60 studies), 95% CI 16.1-24.4
19.9%
Range between studies
2.5%-66.3%
Heterogeneity I2 (p < 0.0001)
97%
Further pooled results
Definition thresholds
- MAP thresholds varied considerably
- <50-80 mmHg
- Cardiac index thresholds varied considerably
- 2.0-3.5 L·min-1m-2
- Vasopressor dosages differed between definitions
Effect of vasoplegia on ICU LOS
- Very heterogeneous among studies, I2
- 99%
Effect of vasoplegia on 30-day mortality
- Very heterogeneous among studies, I2
- 73%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Vasoplegia in Cardiac Surgery: A Systematic Review and Meta-analysis of Current Definitions and Their Influence on Clinical Outcomes. J Cardiothorac Vasc Anesth. Published 21 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →