Cardiothoracic & vascular anesthesia
Vasoplegic Syndrome during Left Ventricular Assist Device Insertion: A Systematic Review and Meta-Analysis
Authors' conclusion
VS affects approximately one-third of LVAD recipients and is associated with substantially increased postoperative morbidity and mortality.
Study context
- Population
- Adults undergoing durable left ventricular assist device (LVAD) insertion via cardiopulmonary bypass (CPB)
- Participants
- 3,121 adults · 16 retrospective studies
- Comparison
- Vasoplegic syndrome (VS) vs no VS after durable LVAD insertion
- VSn = 1,093
- Outcome
- Pooled VS incidence
Methodological detailsPRISMA, Newcastle-Ottawa Scale risk of bias
- PRISMA
- Newcastle-Ottawa Scale risk of bias
Pooled result
As reported in the abstract
Pooled VS incidence
36.30%
95% CI 34.61%–38.02%
Further pooled results
Risk factors for VS
| RR | P value | |
|---|---|---|
| Male sex | 1.65 | P = 0.008 |
| INTERMACS profile ≤2 | 1.19 | P = 0.009 |
| Repeat sternotomy | 1.30 | P = 0.020 |
| Concomitant procedures | 1.27 | P = 0.003 |
| Outcome | No VS | WMD (minutes) | P value |
|---|---|---|---|
| Risk factors for VSLonger CPB duration | 13.17 | P < 0.001 | |
| ICU LOSVS vs No VS | 6.34 days | P < 0.001 | |
| Mortality · 30 daysVS vs No VS | 5.63% | P < 0.001 | |
| Mortality · 1 yearVS vs No VS | 22.62% | P = 0.030 |
- ICU LOS: VS 10.00 days
- Mortality: VS 14.85%
- Mortality: VS 33.88%
Safety
| Outcome | OR | P value |
|---|---|---|
| Postoperative complicationsVS vs No VS · right ventricular failure | 1.76 | P < 0.001 |
| Postoperative complicationsVS vs No VS · RRT | 1.77 | P < 0.001 |
| Postoperative complicationsVS vs No VS · reoperation for bleeding | 2.46 | P < 0.001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Vasoplegic Syndrome during Left Ventricular Assist Device Insertion: A Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. Published 13 July 2026. doi:10.
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