Cardiac arrest & resuscitation
Veno‐arterial CO2 difference and lactate for prediction of early mortality after cardiac arrest
Primary result · 96-h mortalityResult — go to the resultAdjusted odds ratio 1.15 95% CI 1.02–1.29Authors' conclusion
Our results do not support the use of ∆pCO2 to identify patients with early mortality in the postresuscitation phase. In contrast, non-survivors demonstrated higher lactate levels in the initial phase and lactate identified patients with early mortality with moderate accuracy.
Study context
- Population
- Patients admitted to intensive care after cardiac arrestincluded in the analysis
- Participants
- 163 patients
- Comparison
- ∆pCO2 vs lactate for prediction of 96-h mortality
- Primary endpoint
- Association with and prognostic value for 96-h mortality
- Follow-up
- 96 h
Methodological detailspre-planned, prognostic, 5 Swedish sites, Repeated measurements at 4, 8, 12, 16, 24, 48, and 72 h after randomization
- Pre-planned
- Prognostic
- 5 Swedish sites
- Repeated measurements at 4, 8, 12, 16, 24, 48, and 72 h after randomization
Primary result
96-h mortality
Adjusted odds ratio
1.15
95% CI 1.02–1.29
P = 0.018
By group
∆pCO2
0.59
0.48–0.74
AUC (95% CI)
Lactate
0.82
0.72–0.92
AUC (95% CI)
∆pCO2 vs lactate for prediction of 96-h mortality
aOR 1.15 (95% CI 1.02–1.29); P = 0.018
As reported in the abstract
- Mortality at 96 h
- 17%
Original publication
Veno‐arterial CO2 difference and lactate for prediction of early mortality after cardiac arrest. Acta Anaesthesiol Scand. Published 16 March 2023. doi:10.
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