Veno‐venous extracorporeal membrane oxygenation for severe COVID ‐19 associated acute respiratory distress syndrome: A retrospective, nationwide, Danish cohort study
Authors' conclusion
A nationwide, Danish cohort study of 68 COVID-19 patients supported with V-V ECMO, showed a 90-day survival of 43%, which is in accordance with reports from comparable cohorts. Age of 60 years or more was associated with an increased risk of mortality. Pre-existing hypertension was associated with a decreased risk of mortality.
Study context
- Population
- Patients with COVID-19 associated ARDS supported with V–V ECMO in Denmark, March 10, 2020, to December 31, 2021cannulated for V–V ECMO
- Participants
- 68 patients
- Outcome
- Mortality
- Follow-up
- 90 days
Methodological detailsnationwide, 197 enquiries for ECMO; 118 considered eligible; 71 cannulated (3 V-A ECMO for right sided HF, 68 V-V ECMO); 2 accepted for V-V ECMO died during cannulation
- Nationwide
- 197 enquiries for ECMO; 118 considered eligible; 71 cannulated (3 V-A ECMO for right sided HF, 68 V-V ECMO); 2 accepted for V-V ECMO died during cannulation
Main finding
As reported in the abstract
90-day mortality
V-V ECMO
43%
Observational data: associations, not effects.
Further findings
Duration of ECMO support
- Median duration of ECMO support
- 13 days (IQR 7-21)
Duration of mechanical ventilation
- Median duration of mechanical ventilation
- 26 days (IQR 14-42)
ICU LOS
- Median ICU stay
- 34 days (IQR 17-46)
Hospital LOS
- Median length of hospital stay
- 41 days (IQR 25-56)
Risk factors for mortality (multivariate Cox regression)
- Age ≥60 years associated with increased risk of mortality
- Pre-existing hypertension associated with decreased risk of mortality
Original publication
Veno‐venous extracorporeal membrane oxygenation for severe COVID ‐19 associated acute respiratory distress syndrome: A retrospective, nationwide, Danish cohort study. Acta Anaesthesiol Scand. Published 22 October 2024. doi:10.
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