Respiratory failure & ventilation
Very Low Driving-Pressure Ventilation in Patients With COVID-19 Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation: A Physiologic Study
Authors' conclusion
Biomarkers did not significantly change with decreased ΔPs or Vt changes during the first 24 hours post-ECMO.
Study context
- Population
- Adults with severe COVID-19 acute respiratory distress syndrome (ARDS) on VV ECMO, single university medical centre21 underwent very low driving-pressure ventilation (V-LDPV)
- Participants
- 26 adults
- Exposure
- Low-driving-pressure ventilation (LDPV) vs V-LDPV
- V-LDPVn = 21
- Outcome
- Plasma biomarkers of inflammation and lung injury (IL-6, IL-8, sRAGE)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
IL-6, IL-8 and sRAGE
- No significant change in IL-6, IL-8 and sRAGE from LDPV to V-LDPV and from V-LDPV to LDPV
Observational data: associations, not effects.
Further findings
Vt in participants with nonspontaneous breaths (9 of 21)
- Vt (mean ± SD), first value reported, mL/kg predicted body weight (PBW)
- 1.9 ± 0.5
- Vt (mean ± SD), second value reported, mL/kg PBW
- 0.1 ± 0.2
- Vt (mean ± SD), third value reported, mL/kg PBW
- 2.0 ± 0.7
- Significant change in Vt
- P < 0.001
Vt in participants with spontaneous breathing
- Vt (mean ± SD), first value reported, mL/kg PBW
- 4.5 ± 3.1
- Vt (mean ± SD), second value reported, mL/kg PBW
- 4.7 ± 3.1
- Vt (mean ± SD), third value reported, mL/kg PBW
- 5.6 ± 2.9
- Vt unchanged
- P = 0.481 and p = 0.065, respectively
Biomarkers accounting for Vt changes
- No relationship found
Original publication
Very Low Driving-Pressure Ventilation in Patients With COVID-19 Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation: A Physiologic Study. J Cardiothorac Vasc Anesth. Published 28 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →