ICU sedation, delirium & recovery
Vitamin K: a potential missing link in critical illness–a scoping review
Authors' conclusion
Addressing vitamin K deficiency in ICU patients is crucial for mitigating risks associated with critical illness, yet optimal management strategies require further investigation.
Study context
- Population
- Adult ICU patients with vitamin K deficiency and/or supplementation13 studies
- Outcome
- Vitamin K deficiency in ICU patients
Methodological detailsPRISMA Extension for Scoping Reviews, Literature search December 2023 in PubMed, Embase and Cochrane without restrictions
- PRISMA Extension for Scoping Reviews
- Literature search December 2023 in PubMed, Embase and Cochrane without restrictions
Main finding
As reported in the abstract
- Deficiency linked to malnutrition, impaired absorption, antibiotic use, increased turnover and genetic factors
- Observational studies show higher PIVKA-II levels in ICU patients, indicating reduced vitamin K status
- Supplementation can improve status but not normalize it completely
- Deficiency may correlate with prolonged ICU stay, mechanical ventilation and increased mortality
- 1712 articles screened
Original publication
Vitamin K: a potential missing link in critical illness–a scoping review. Crit Care. Published 1 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →