Respiratory failure & ventilation
Weaning from mechanical ventilation in the operating room: a systematic review
Authors' conclusion
Based on low-quality evidence, PSV, individualised PEEP, and low FiO2 may be associated with reduced postoperative pulmonary outcomes.
Study context
- Population
- Adults weaned from mechanical ventilation (MV) in the operating room
- Participants
- 1,719 adults · 14 RCTs
- Comparison
- Weaning strategies from intraoperative MV
- Outcome
- Atelectasis and oxygenation
Methodological detailsRisk of Bias (RoB2) risk of bias assessment, GRADE, 7 studies limited to the weaning phase; 7 included interventions not restricted to it
- RoB2 risk of bias assessment
- GRADE
- 7 studies limited to the weaning phase; 7 included interventions not restricted to it
Pooled result
As reported in the abstract
- Pressure support ventilation (PSV) with positive end-expiratory pressure (PEEP) and low fraction of inspired oxygen (FiO2) improved atelectasis, oxygenation and lung volumes
- Low FiO2 improved atelectasis and oxygenation but might not improve lung volumes
- Fixed-PEEP strategy: no improvement in oxygenation or atelectasis
- Individualised PEEP with low FiO2 improved oxygenation
- Half of studies moderate or high risk of bias; overall quality of evidence low
Further pooled results
- Individualised PEEP with low FiO2 might be associated with reduced postoperative pulmonary complications (PPCs)
Original publication
Weaning from mechanical ventilation in the operating room: a systematic review. Br J Anaesth. Published 29 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →