0.25% bupivacaine–1% lidocaine vs 0.5% bupivacaine for ultrasound-guided infraclavicular brachial plexus block: a randomized controlled trial
Primary result · Motor block durationResult — go to the resultMean difference 9.5 hours 95% CI 6.5–12.4Authors' conclusion
Compared with mixed bupivacaine-lidocaine, 0.5% bupivacaine significantly prolongs sensorimotor block and postoperative analgesia at the expense of a delayed onset time.
Study context
- Population
- Patients receiving ultrasound-guided infraclavicular brachial plexus block
- Participants
- 40 patients
- Comparison
- 0.5% bupivacaine vs 0.25% bupivacaine–1% lidocaine
- Primary endpoint
- Duration of motor block
Methodological detailsblinded outcome assessment
- Blinded outcome assessment
Primary result
Motor block duration
Mean difference
9.5 hours
95% CI 6.5–12.4
P < 0.001
By group
Bupivacaine vs Bupivacaine-lidocaine
mean difference 9.5 hours (95% CI 6.5–12.4); P < 0.001
As reported in the abstract
Further findings
Mean, hours
| Outcome | Bupivacaine | Bupivacaine-lidocaine | Mean difference (hours) (95% CI) | P value | |
|---|---|---|---|---|---|
| Sensory block duration | 29.3 (SD 5.8) | 18.7 (SD 4.0) | 10.6 (7.1–14.0) | P < 0.001 | |
| Postoperative analgesia duration | 38.3 (SD 7.4) | 24.3 (SD 6.6) | 14 (9.2–18.8) | P < 0.001 | |
| −1001020Difference, hours (linear scale) |
Onset time
P < 0.001
Other outcomes (block success, surgical anaesthesia, rebound pain)
- No other significant differences were detected
Original publication
0.25% bupivacaine–1% lidocaine vs 0.5% bupivacaine for ultrasound-guided infraclavicular brachial plexus block: a randomized controlled trial. Reg Anesth Pain Med. Published 16 May 2024. doi:10.
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