A Comparison of the Analgesia Nociception Index and Nociception Level Index Under General Anesthesia With Propofol and Remifentanil
Authors' conclusion
The modest agreement between ANI and NOL underscores discrepancies likely stemming from their different methodological approaches.
Study context
- Population
- Adults undergoing GA with propofol and remifentanil TCI
- Participants
- 30 adults
- Exposure
- Analgesia Nociception Index (ANI) vs NOL nociception monitoring
- Outcome
- Agreement between monitors on insufficient, adequate or excessive analgesia (manufacturer thresholds)
Methodological detailsconcurrent monitoring, time-matched recordings
- Concurrent monitoring
- Time-matched recordings
Main finding
As reported in the abstract
Agreement between ANI and NOL
Monitors agreed (% of monitoring time)
43.7%
1-category disagreement (% of recordings)
37.1%
2-category disagreement (% of recordings)
8.7%
Observational data: associations, not effects.
Further findings
Excessive analgesia (% of surgical time)
Optimal and insufficient analgesia (% of time)
- Each monitor reported insufficient analgesia
- 25%
- Each monitor reported optimal analgesia around 31% of the time
Original publication
A Comparison of the Analgesia Nociception Index and Nociception Level Index Under General Anesthesia With Propofol and Remifentanil. Anesth Analg. Published 11 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →