Comparison of different monitors for measurement of nociception during general anaesthesia: a network meta-analysis of randomised controlled trials
Authors' conclusion
Apart from pupillometry, no monitors demonstrated a significant effect on intraoperative opioid consumption.
Study context
- Population
- Adults under GA
- Participants
- 3,412 participants · 38 RCTs
- Comparison
- Nociception monitors vs standard care or vs each other
- Outcome
- Intraoperative opioid consumption (SMD of morphine equivalents)
Methodological detailsRoB 2.0 risk of bias assessment
- RoB 2.0 risk of bias assessment
Pooled result
As reported in the abstract
Intraoperative opioid consumption
SMD, ME (95% CrI)
Pupillometry vs Standard care
−2.44(−4.35 to −0.52)
Pupillometry vs SPI
−2.99(−5.15 to −0.81)
Further pooled results
Time to discharge readiness from PACU
- Pupillometry associated with longer time to discharge readiness
Extubation time
- NOL associated with shorter extubation times
Other secondary outcomes (postoperative opioid consumption, nausea or vomiting, pain score)
- No relevant differences
Original publication
Comparison of different monitors for measurement of nociception during general anaesthesia: a network meta-analysis of randomised controlled trials. Br J Anaesth. Published 28 November 2024. doi:10.
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