Cardiothoracic & vascular anesthesia
A Modified 4Ts Score for Heparin-Induced Thrombocytopenia in the Mechanical Circulatory Support Population
Authors' conclusion
Heparin-induced thrombocytopenia is associated with worse outcomes and increased morbidity and mortality in the MCS population.
Study context
- Population
- Adults who underwent cardiac surgery, single tertiary-care center, May 2008–December 2016
- Participants
- 5,314 adults
- Exposure
- 4TMCS vs 4Ts probability score for heparin-induced thrombocytopenia (HIT)
- Outcome
- Diagnostic accuracy for HIT
Methodological detailssingle-centre, diagnostic accuracy comparison
- Single-centre
- Diagnostic accuracy comparison
Main finding
As reported in the abstract
| Strategy | AUC | Sensitivity (cutoff ≥4) |
|---|---|---|
| 4TMCS | 0.83 | 95.2% |
| 4Ts | 0.77 | 85.7% |
AUC
4TMCS0.83
4Ts0.77
Sensitivity (cutoff ≥4)
4TMCS95.2%
4Ts85.7%
- 4TMCS vs 4Ts: P < 0.044
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| In-hospital mortality | HIT(+) 25.6% · HIT(-) 11.7% · Control 1.5% | |
| HIT incidence by MCSMCS vs No MCS | MCS 5.9% · No MCS 1.9% | P < 0.001 |
- In-hospital mortality: p < 0.001
HIT incidence
- Diagnosed with HIT
- 125 out of 5,314 patients (2.4%)
- HIT with clinical evidence of thrombosis
- 75 out of 5,314 (1.4%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Modified 4Ts Score for Heparin-Induced Thrombocytopenia in the Mechanical Circulatory Support Population. J Cardiothorac Vasc Anesth. Published 24 June 2023. doi:10.
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