Respiratory failure & ventilation
A pragmatic calibration of the ROX index to predict outcome of nasal high-flow therapy in India
Authors' conclusion
When optimally calibrated this index can using a method that can reliably predict the risk of HFNC failure among ICU patients from diverse settings.
Study context
- Population
- Patients ≥18 years requiring HFNC for respiratory support in 30 diverse ICUs across 10 states in India
- Participants
- 614 patients · 30 ICUs
- Outcome
- HFNC failure prediction by ROX index
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Respiratory escalation
276
44.9%
Baseline ROX score threshold (ROC analysis), similar to 4.88 in other populations
7.86
HR for HFNC failure below baseline ROX threshold (Kaplan-Meier)
3.58
2.72–4.69p < 0.001
ROX scores for screening and confirming HFNC failure
11.84 or 5.89
Observational data: associations, not effects.
Further findings
Patients who died without respiratory escalation (subgroup)
- ROX index performed poorly
Timing and HFNC duration
- ROX index most predictive in initial hours of ICU admission; longer HFNC duration associated with more severe outcomes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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