Respiratory failure & ventilation
Serially measured diaphragmatic thickening fraction, but not diaphragmatic excursion, was associated with subsequent intubation during high-flow nasal cannula therapy: a prospective repeated-measures cohort study
Main finding · IntubationResult — go to the resultOdds ratio 1.50 95% CI 1.29–1.74Authors' conclusion
Serially measured DTF, but not DE, was associated with subsequent intubation risk.
Study context
- Population
- Consecutive adults with acute hypoxemic respiratory failure receiving high-flow nasal cannula (HFNC), ICU1,221 person-period records
- Participants
- 270 adults
- Exposure
- Serial diaphragmatic excursion (DE) and diaphragmatic thickening fraction (DTF) vs subsequent intubation during HFNC
- Outcome
- Intubation
- Follow-up
- Within 48 h of HFNC initiation
Methodological detailssingle-center, repeated-measures, Right-sided diaphragm ultrasound at HFNC initiation and 1, 3, 6, 9, and 12 h; 1491 assessments
- Single-center
- Repeated-measures
- Right-sided diaphragm ultrasound at HFNC initiation and 1, 3, 6, 9, and 12 h; 1491 assessments
Main finding
As reported in the abstract
within 48 h
Odds ratio
1.50
95% CI 1.29–1.74
P < 0.001
DTF, per 1-SD increase (35.7 percentage points)
OR 1.50 (95% CI 1.29–1.74); P < 0.001
Per 1-SD increase, as printed
- Intubated
- 64 (23.7%)
Observational data: associations, not effects.
Further findings
| Outcome | Delta AUC (95% CI) |
|---|---|
| Discrimination: adding DTF to ROXROX + DTF vs ROX · cluster-bootstrap CI; apparent AUC 0.707 to 0.736 | 0.029 (0.009–0.055) |
Discrimination: adding DTF to ROX
- ROX remained the stronger bedside marker
- Adding DE provided little improvement
Next-window prediction (sensitivity analysis)
- Directionally consistent
Original publication
Serially measured diaphragmatic thickening fraction, but not diaphragmatic excursion, was associated with subsequent intubation during high-flow nasal cannula therapy: a prospective repeated-measures cohort study. J Crit Care. Published 2 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →