Hemodynamics, fluids & transfusion
A Propensity-Matched Cohort Study of Intravenous Iron versus Red Cell Transfusions for Preoperative Iron-Deficiency Anemia
Main finding · Postoperative mortalityResult — go to the resultRelative risk 0.63 95% CI 0.60–0.66Authors' conclusion
In a risk-adjusted analysis, preoperative IDA treatment with IV iron compared to RBC transfusion was associated with a reduction in 30-day postoperative mortality and morbidity, a higher 30-day postoperative hemoglobin level, and reduced postoperative RBC transfusion.
Study context
- Population
- Surgical patients diagnosed with iron-deficiency anemia (IDA) within 3 months preoperatively, 2003–2023propensity-matched cohorts
- Participants
- 77,179 vs 77,179
- Exposure
- Preoperative intravenous (IV) iron vs preoperative RBC transfusion
- IV ironn = 77,179
- RBC transfusionn = 77,179reference
- Outcome
- Postoperative mortality
- Follow-up
- 30 days
Methodological detailspropensity-score matched, national database (TriNetX Research Network)
- Propensity-score matched
- National database (TriNetX Research Network)
Main finding
As reported in the abstract
Relative risk
0.63
95% CI 0.60–0.66
P = 0.001
Events by group
IV iron vs RBC transfusion
RR 0.63 (95% CI 0.60–0.66); P = 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | IV iron | RBC transfusion | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative composite morbidity · 30 daysAfter Bonferroni adjustment | 18.4% | 24.1% | 0.76 (0.75–0.78) | P = 0.001 | |
| Postoperative RBC transfusion · 30 days | 4.9% | 16.4% | 0.30 (0.29–0.31) | ||
| 0.20.5125Relative risk (log scale) |
Postoperative hemoglobin · 30-day postoperative period · after Bonferroni adjustment
P = 0.001
Original publication
A Propensity-Matched Cohort Study of Intravenous Iron versus Red Cell Transfusions for Preoperative Iron-Deficiency Anemia. Anesth Analg. Published 22 July 2024. doi:10.
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