A prospective observational study of the effects of sugammadex on peri‐operative oestrogen and progesterone levels in women who take hormonal contraception
Authors' conclusion
We found no evidence of a change in hormone levels that might threaten contraceptive efficacy in women on hormonal contraception receiving sugammadex.
Study context
- Population
- Premenopausal adult women undergoing an operative procedure
- Participants
- 60 / 30 / 32
- Exposure
- Hormonal contraception + sugammadex vs no contraception without sugammadex vs no contraception + sugammadex
- Contraception + sugammadexn = 60
- No contraception, no sugammadexn = 30reference
- No contraception + sugammadexn = 32reference
- Outcome
- Changes in serum oestrogen and progesterone concentrations
- Follow-up
- 15 min and 240 min post-sugammadex or end of operating theatre time
Methodological detailsBlood samples before sugammadex, 15 min and 240 min post-sugammadex or end of operating theatre time
- Blood samples before sugammadex, 15 min and 240 min post-sugammadex or end of operating theatre time
Main finding
As reported in the abstract
Serum oestrogen and progesterone levels
- Median oestrogen decreased from baseline by around 40% at 240 min in all three groups
- p ≤ 0.001
- Progesterone rose significantly at 15 min in patients on contraception
- p = 0.002
Observational data: associations, not effects.
Original publication
A prospective observational study of the effects of sugammadex on peri‐operative oestrogen and progesterone levels in women who take hormonal contraception. Anaesthesia. Published 6 November 2022. doi:10.
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