Cardiothoracic & vascular anesthesia
A Randomized Controlled Trial Comparing Effectiveness of Different Fibrinogen Preparations in Restoring Clot Firmness
Authors' conclusion
In contrast to previous in vitro studies, we found that the effect of FibCLOT on MCF and CT was not significantly greater than that of RiaSTAP in cardiac surgery patients.
Study context
- Population
- Cardiac surgery patients with microvascular bleeding and FIBTEM maximum clot firmness (MCF) <10 mm after protamine
- Participants
- 40 patients
- Comparison
- FibCLOT vs RiaSTAP fibrinogen concentrate 30 mg/kg
- Primary endpoint
- Increase in clot firmness (FIBTEM MCF)
Primary result
As reported in the abstract
Increase in FIBTEM MCF
FibCLOT
4
mean · SD 1.2 · mm
RiaSTAP
4
mean · SD 1.6 · mm
P = 1.000
Further findings
| Outcome | FibCLOT | RiaSTAP | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| No increase of 4 mm in FIBTEM MCF | 20% | 35% | 2.15 (0.52–9.00) | P = 0.288 | |
| 0.10.31310Relative risk (log scale) |
| Outcome | FibCLOT | RiaSTAP | P value |
|---|---|---|---|
| Decrease in EXTEM clotting time (CT) | mean 11. 2 (SD 12.2) seconds | — not stated in the abstract | P = 0.372 |
— not stated in the abstract
Change from before to after fibrinogen supplementation, within groups
- Significant increase in FIBTEM MCF and EXTEM clotting time (CT) in both groups
- P = 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Randomized Controlled Trial Comparing Effectiveness of Different Fibrinogen Preparations in Restoring Clot Firmness. Anesth Analg. Published 9 October 2024. doi:10.
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