A Slow-Exchange Interstitial Fluid Compartment in Volunteers and Anesthetized Patients: Kinetic Analysis and Physiology
Authors' conclusion
Kinetic analysis supported that Ringer's solution distributes in 2 interstitial compartments with different turnover times. The slow compartment became dominant when large amounts of fluid were infused and during general anesthesia.
Study context
- Population
- Awake and anesthetized humans given IV Ringer's solution 238–2750 mL (mean 1487 mL); mean age 39 years, 47% females
- Participants
- 270 experiments
- Exposure
- GA vs awake; infusion time and volume
- Outcome
- Sizes and turnover rates of interstitial fluid compartments (volume kinetics from urinary excretion and hemoglobin-derived plasma dilution)
Methodological detailsmechanistic study, mixed-models volume kinetic analysis, pooled retrospective data
- Mechanistic study
- Mixed-models volume kinetic analysis
- Pooled retrospective data
Main finding
As reported in the abstract
GA increased rate constant for fluid entering fast-exchange compartment (min −1)
from 0.072 to 0.155
GA increased rate constant for fluid entering slow-exchange compartment (min −1)
from 0.026 to 0.080
Return rate constant, fast-exchange compartment, infusion time 15 to 60 minutes
from 0.251 to 0.050
Return rate constant, slow-exchange compartment, infused volume 500 to 1500 mL
from 0.019 to 0.005
Observational data: associations, not effects.
Original publication
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