Respiratory failure & ventilation
A targeted metabolomics approach for sepsis-induced acute respiratory distress syndrome (ARDS) and its subphenotypes
Authors' conclusion
Our study demonstrated a marked difference in metabolic patterns between sepsis-induced ARDS patients and non-ARDS controls, and between sepsis-induced direct and indirect ARDS subpheonotypes.
Study context
- Population
- Sepsis registry patients, prospectively collected March 2011 to February 2018
- Participants
- 54 vs 30
- Exposure
- Sepsis-induced ARDS vs non-ARDS controls; sepsis-induced direct vs indirect ARDS
- ARDSn = 54
- Non-ARDS controlsn = 30reference
- Outcome
- Metabolites distinguishing sepsis-induced ARDS from non-ARDS controls and direct from indirect ARDS
Methodological detailstargeted metabolomics, sepsis registry samples, LC-MS/MS and GC-MS
- Targeted metabolomics
- Sepsis registry samples
- LC-MS/MS and GC-MS
Main finding
As reported in the abstract
Metabolites detected
186
Metabolites differentiating sepsis-induced ARDS from non-ARDS controls
102
Metabolites discriminating sepsis-induced ARDS subphenotypes
14
Observational data: associations, not effects.
Original publication
A targeted metabolomics approach for sepsis-induced ARDS and its subphenotypes. Crit Care. Published 5 July 2023. doi:10.
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