Respiratory failure & ventilation
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients
Authors' conclusion
Neither mechanical power nor its components were independently associated with mortality in COVID-19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and total elastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure, however, captured this risk in a similar manner.
Study context
- Population
- Patients with COVID-19-induced acute respiratory failure on invasive mechanical ventilation, 50 Spanish ICUs, February 2020–December 2021
- Participants
- 799 patients
- Comparison
- Mechanical power and its components and 90-day mortality
- Primary endpoint
- 90-day mortality
- Follow-up
- 90 days
Methodological detailsmultivariable regression
- Multivariable regression
Primary result
As reported in the abstract
Association of mechanical power and its components with 90-day mortality at start of mechanical ventilation · initiation of mechanical ventilation
- Mechanical power and its components not associated with 90-day mortality at start of mechanical ventilation (multivariable regression)
Further findings
Mechanical power at initiation of mechanical ventilation
- Mechanical power (J/min), no significant changes after three days
- 24.3 (18.9; 29.6)
Baseline respiratory variables at initiation of mechanical ventilation
- PaO2/FiO2 ratio
- 106 (78; 150)
- Ventilatory ratio
- 1.69 (1.40; 2.05)
- Respiratory system compliance (ml/cmH2O)
- 35.7 (29.2; 44.5)
Association with 90-day mortality after three days of mechanical ventilation
- Total elastic and elastic static power associated with higher 90-day mortality; relationship also found for PEEP
Original publication
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients. Ann Intensive Care. Published 25 February 2025. doi:10.
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