Respiratory failure & ventilation
A tidal volume of 7 mL/kg predicted body weight (PBW) or higher may be safe for coronavirus disease (COVID-19) patients
Primary result · ICU mortalityResult — go to the resultOdds ratio 0.62 95 % CI 0.40–0.95Authors' conclusion
A tidal volume ≥ 7 (up to 9) mL/kg PBW was associated with lower ICU mortality in these COVID-19 patients, including those with compliance <40 mL/cmH2O.
Study context
- Population
- Ventilated COVID-19 patients; compliance categorized as <40, 40–50, or > 50 mL/cmH2O
- Participants
- 600 patients
- Comparison
- Tidal volume ≥7 vs <7 mL/kg PBW
- ≥7n = 254
- <7n = 346reference
- Primary endpoint
- ICU mortality
Methodological detailsretrospective
- Retrospective
Primary result
As reported in the abstract
Odds ratio
0.62
95 % CI 0.40–0.95
By group
≥7 vs <7
OR 0.62 (95 % CI 0.40–0.95)
Further findings
Intensive Care Unit (ICU) mortality by compliance category (subgroup)
- Tidal volume ≥ 7 mL/kg PBW associated with lower ICU mortality in each compliance category
- Multivariable regression
Original publication
A tidal volume of 7 mL/kg PBW or higher may be safe for COVID-19 patients. J Crit Care. Published 25 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →