Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial
Authors' conclusion
One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI.
Study context
- Population
- Patients undergoing major surgery without pre-existing chronic kidney disease (CKD) (plus a separate cohort with pre-existing CKD)without pre-existing CKD
- Participants
- 9,510 patients
- Primary endpoint
- Incidence of AKD (new onset eGFR < 60 ml/min/1.73 m² on day 7 or later) among survivors
- Follow-up
- Day 7 or later
Methodological detailsinternational, prospective, observational, multicentre
- International
- Prospective
- Observational
- Multicentre
Primary result
As reported in the abstract
AKD after 7 days
Acute kidney disease (AKD) after 7 days (940 patients)
9.9%
Of AKD patients, early postoperative acute kidney injury (AKI)
34.1%
Secondary outcomes
AKD rate by early postoperative AKI severity
- KDIGO 1
- 19.1%
- KDIGO2
- 24.5%
- KDIGO3
- 34.3%
- P < 0.001
AKD rate by early postoperative AKI duration
- Transient AKI
- 15.5%
- Persistent AKI
- 38.3%
- P < 0.001
Independent association of early postoperative AKI with AKD
- Independent OR for AKD
- 2.64 (95% CI 2.21-3.15)
- Other independent risk factors: perioperative nephrotoxic agents, postoperative pneumonia
Worsening CKD in pre-existing CKD (663 patients) · day 90
- Worsening CKD (42 patients)
- 6.3%
- CKD progression with early AKI
- 11.6%
Original publication
Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial. Intensive Care Med. Published 29 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →