Cardiothoracic & vascular anesthesia
Acute kidney disease and postoperative glycemia variability in patients undergoing cardiac surgery: A multicenter cohort analysis of 8,090 patients
Authors' conclusion
Our study highlights the association between postoperative GV and increased AKD risk, and identifies specific GV thresholds in adults undergoing cardiac surgery.
Study context
- Population
- Adults undergoing cardiac surgery with CPB at three academic medical centres in Eastern China, 2015–2023
- Participants
- 8,090 adults
- Exposure
- Postoperative glycemic variability and acute kidney disease (AKD) risk
- Outcome
- Acute kidney disease (AKD), categorised as persistent or delayed AKD by acute kidney injury (AKI) status in the first 7 days
- Follow-up
- 8–90 days post-surgery
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
AKD · 8-90 days postoperative
Standardized hazard ratio (95% CI)
GV (SD)
1.20(1.12–1.27)
GV (TOR)
1.30(1.20–1.40)
- AKD incidence
- 522 out of 8,090 (6.5%)
- 7-day postoperative glycemic variability (GV) significantly higher in AKD patients (each metric)
- P < 0.001
Observational data: associations, not effects.
Further findings
AKD subtypes
- GV correlated with persistent AKD; no statistically significant association with delayed AKD
Original publication
Acute kidney disease and postoperative glycemia variability in patients undergoing cardiac surgery: A multicenter cohort analysis of 8,090 patients. J Clin Anesth. Published 26 November 2024. doi:10.
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