Cardiothoracic & vascular anesthesia
Effects of remimazolam and propofol on parasympathetic activity during general anesthesia induction in patients with severe aortic stenosis: a randomized controlled trial utilizing high-frequency variability index
Authors' conclusion
These findings suggest that remimazolam may be associated with distinct autonomic responses during anesthesia induction.
Study context
- Population
- Patients with severe aortic stenosis scheduled for elective transcatheter aortic valve replacement, tertiary emergency medical facility
- Participants
- 28 patients
- Comparison
- Remimazolam vs propofol for anaesthesia induction
- Primary endpoint
- Difference in mean high-frequency variability index (HFVI) between the 3-min period before and after induction
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
ΔHFVI (decrease after induction)
Remimazolam
16
Propofol
3
P = 0.010
Further findings
| Outcome | P value |
|---|---|
| Heart rateIncreased with remimazolam, decreased with propofol | P = 0.006 |
Baseline high-frequency variability index (HFVI)
- No significant difference between groups
Other hemodynamic parameters (MAP, CO, stroke volume variation, pulse pressure variation, dynamic arterial elastance)
- No significant intergroup differences
Original publication
Effects of remimazolam and propofol on parasympathetic activity during general anesthesia induction in patients with severe aortic stenosis: a randomized controlled trial utilizing high-frequency variability index. J Clin Monit Comput. Published 2 April 2026. doi:10.
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