Cardiothoracic & vascular anesthesia
General Anesthesia Versus Local Anesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement: An Updated Meta-Analysis and Systematic Review
Pooled result · 30-day mortalityResult — go to the resultRelative risk 0.69Authors' conclusion
Transcatheter aortic valve replacement performed using LA is associated with lower rates of adverse clinical outcomes, including 30-day mortality and stroke.
Study context
- Population
- Patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR)
- Participants
- 14,388 patients · 40 studies
- Comparison
- Local anesthesia (LA) vs general anesthesia (GA) for TAVR
- LAn = 7,754
- GAn = 6,634reference
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsrandom effects, pairwise, Mantel-Haenszel method
- Random effects
- Pairwise
- Mantel-Haenszel method
Pooled result
As reported in the abstract
Relative risk
0.69
P < 0.01
Further pooled results
| Outcome | RR | P value |
|---|---|---|
| Stroke | 0.78 | P = 0.02 |
| Long-term mortality | 0.75 | P = 0.009 |
| 30-day paravalvular leak · no significant difference | 0.88 | P = 0.12 |
Safety
| Outcome | RR | P value |
|---|---|---|
| 30-day major and/or life-threatening bleeding | 0.64 | P = 0.01 |
| 30-day major vascular complications | 0.76 | P = 0.02 |
Original publication
General Anesthesia Versus Local Anesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement: An Updated Meta-Analysis and Systematic Review. J Cardiothorac Vasc Anesth. Published 14 March 2023. doi:10.
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