Cardiac arrest & resuscitation
Acute liver failure after out-of-hospital cardiac arrest: An observational study
Authors' conclusion
ALF occurred frequently after OHCA and, unlike HH, was independently associated with day 28 mortality.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients admitted to two ICUs, 2007–2017
- Participants
- 418 patients
- Exposure
- Acute liver failure (ALF) vs no ALF at admission after OHCA
- ALFn = 67
- Outcome
- Mortality (association of ALF with death)
- Follow-up
- Day 28
Methodological detailstwo ICUs
- Two ICUs
Main finding
As reported in the abstract
Day 28 mortality
Overall day 28 deaths
337
80.6%
Observational data: associations, not effects.
Further findings
Frequency of ALF and hypoxic hepatitis (HH) at admission
- ALF
- 67 (16.0%)
- HH
- 61 (14.6%)
Indocyanine green (ICG) clearance impairment and correlation with prothrombin time (PT) ratio (CYRUS trial subset)
- ICG clearance impaired (of 22 patients)
- 17 (77.3%)
- PT ratio correlation with ICG clearance
- r = −0.66, p < 0.01
- PT ratio the only static liver function test correlating significantly
Original publication
Acute liver failure after out-of-hospital cardiac arrest: An observational study. Resuscitation. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →