Respiratory failure & ventilation
Acute respiratory distress syndrome in patients with hematological malignancies: a one-year retrospective nationwide cohort study
Authors' conclusion
Mortality remains high in patients with HM admitted in ICU with ARDS in comparison with patients without cancer. Mortality predictors for this population were a diagnosis of lymphoma or acute leukemia, age, a high modified SAPS II score, a renal replacement therapy, invasive fungal infection and a septic shock.
Study context
- Population
- Adults (≥18 years) admitted to French ICUs in 2017 with a diagnosis of acute respiratory distress syndrome (ARDS)
- Participants
- 12,846 adults
- Exposure
- Hematological malignancies (HM) vs solid cancer vs no cancer
- HMn = 990
- Solid cancern = 2,744
- Outcome
- 90-day mortality
- Follow-up
- 90 days
Methodological detailsnationwide, French national hospital database (PMSI)
- Nationwide
- French national hospital database (PMSI)
Main finding
As reported in the abstract
Day-90 mortality
HM vs No cancer: P = 0.01 · HM vs Solid cancer: P = 0.09
Observational data: associations, not effects.
Secondary outcomes
Intubation rate — HM vs Solid cancer · lower in HM
P = 0.02
| Outcome | P value |
|---|---|
| Intubation rateHM vs No cancer · lower in HM | P < 0.01 |
- Main malignancies (HM)
- 28.5% · Non-Hodgkin lymphoma · Acute myeloid leukemia 20.4% · Multiple myeloma 19.7%
Mortality risk factors (HM)
- Independent predictors of mortality: lymphoma or acute leukemia, age, high modified SAPS II score, RRT, invasive fungal infection, septic shock
- Protective: bacterial pneumonia, extrapulmonary infections, NIV
Original publication
Acute respiratory distress syndrome in patients with hematological malignancies: a one-year retrospective nationwide cohort study. Ann Intensive Care. Published 11 September 2024. doi:10.
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