Neuroanesthesia & neurocritical care
Added Value of Late Auditory Evoked Potentials in the Multimodal Prognostication of Patients With Disorders of Consciousness
Authors' conclusion
Integrating late AEPs into multimodal assessments enhances the model's predictive performance.
Study context
- Population
- Patients with disorders of consciousness at the subacute phase after coma onset (median, 20.0 d), single institutionHypoxic-ischemic brain injury (HIBI) in 43.9%
- Participants
- 148 patients
- Exposure
- Model including late auditory evoked potentials (AEPs) (MMN, P3) vs model with well-established markers only, stratified HIBI vs non-HIBI
- Outcome
- Unfavorable outcome (Glasgow Outcome Scale-Extended 1-2)
- Follow-up
- 3 months
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
PPV of absent P3 and MMN responses for unfavorable outcome
| Group | PPV absent P3 | PPV absent MMN |
|---|---|---|
| HIBI | 92.9% | 88.4% |
| non-HIBI | 67.9% | 57.4% |
PPV absent P3
HIBI92.9%
non-HIBI67.9%
PPV absent MMN
HIBI88.4%
non-HIBI57.4%
Observational data: associations, not effects.
Further findings
PPV of EEG malignant patterns and absent reactivity for unfavorable outcome · significantly higher in HIBI, both markers
P = 0.04
PPV EEG malignant patterns
PPV absent reactivity
PPV of EEG malignant patterns and absent reactivity for unfavorable outcome
- Predictive values of neurophysiologic markers generally lower in non-HIBI than HIBI
Original publication
Added Value of Late Auditory Evoked Potentials in the Multimodal Prognostication of Patients With Disorders of Consciousness. Crit Care Med. Published 10 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →