Cardiothoracic & vascular anaesthesia
Adjusted Relationships between Mean Arterial Pressure, Cardiac Index, and Tissue Oxygenation during Off-pump Coronary Bypass
Authors' conclusion
During off-pump coronary artery bypass surgery, cerebral oxygenation was sensitive to both pressure and flow, whereas forearm oxygenation primarily tracked flow.
Study context
- Population
- Patients undergoing off-pump coronary artery bypass surgery1,864 left SctO2
- Outcome
- Joint and conditional associations of MAP and cardiac index with cerebral (SctO2) and forearm (SftO2) tissue oxygenation
Methodological detailsgeneralized additive models, two-dimensional smoothing, bootstrap, Intraoperative 1-Hz signals; more than 20 million eligible observations per cohort
- Generalized additive models
- Two-dimensional smoothing
- Bootstrap
- Intraoperative 1-Hz signals; more than 20 million eligible observations per cohort
Main finding
As reported in the abstract
- SctO2 depended on both mean arterial pressure (MAP) and cardiac index
- MAP-SctO2 slope substantially reduced over MAP 70 to 100 mmHg, mimicking cerebral pressure autoregulation
- SctO2 rose with cardiac index, highest at ≈4.2 l · min −1 · m −2, then plateaued or slightly decreased
- SftO2 sensitive to cardiac index, not MAP; steepest rise at cardiac index ≤2.8, reduced slope over 2.8 to 4.2 l · min −1 · m −2, continued rise at higher cardiac index
Observational data: associations, not effects.
Further findings
Subgroups (age, sex, baseline BP)
- Patterns more prominent in younger patients, females, and baseline BP less than 140/90 mmHg
Original publication
Adjusted Relationships between Mean Arterial Pressure, Cardiac Index, and Tissue Oxygenation during Off-pump Coronary Bypass. Anesthesiology. Published 15 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →