Respiratory failure & ventilation
Adjustments of Ventilator Parameters during Operating Room–to–ICU Transition and 28-Day Mortality
Authors' conclusion
During transition of mechanically ventilated patients from the OR to the ICU, ventilator adjustments resulting in higher MP were associated with a greater risk of 28-day mortality.
Study context
- Population
- Patients undergoing GA with continued, controlled mechanical ventilation in the ICU, 2008–2022
- Participants
- 2,103 patients
- Exposure
- Change in mechanical power (MP) during OR-to-ICU transition and 28-day mortality
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailshospital registry
- Hospital registry
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)P value
Increases in MP
1.10(1.06–1.14)
P < 0.001Per 1 J/min, as printed
Adjusted risk difference (95% CI)
Increases in MP
0.7%(0.4–1.0)
Per 1 J/min, as printed
Observational data: associations, not effects.
Further findings
Ventilator parameter changes at OR-to-ICU transition (1 h before vs 6 h after)
- VT change, ml/kg predicted body weight (IQR −2.0 to −0.2); P < 0.001
- −1.1
- Driving pressure change, cm H2O (IQR −8.2 to −1.2); P < 0.001
- −4.3
- Respiratory rate change, breaths/min (IQR 2.0 to 7.5); P < 0.001
- +5.0
- MP change, J/min (IQR −1.9 to 3.0); P < 0.001
- +0.7
Original publication
Adjustments of Ventilator Parameters during Operating Room–to–ICU Transition and 28-Day Mortality. Am J Respir Crit Care Med. Published 1 March 2024. doi:10.
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