Hemodynamics, fluids & transfusion
Adverse Events of Peripherally Administered Norepinephrine During Surgery: A Prospective Multicenter Study
Authors' conclusion
Extravasation of peripherally administrated norepinephrine in the perioperative period occurred at similar rates as in previous studies in critically ill patients. In our setting, where we regularly inspected the infusion site and shifted site in case of swelling or paleness of skin, we observed no case of severe adverse events.
Study context
- Population
- Patients undergoing surgery meeting criteria for perioperative peripheral norepinephrine, 3 Swedish hospitals, 2019–2022
- Participants
- 1,004 patients · 3 hospitals
- Outcome
- Prevalence of extravasation (swelling around the infusion site)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Extravasation of infusion
2.3%
95% CI 1.4%–3.2%
Observational data: associations, not effects.
Secondary outcomes
- Proximal catheter placement associated with more adverse events
Safety
Bradycardia (pulse <40 beats•min −1)
- Bradycardia
- 0.9% (95% CI, 0.4%-1.7%)
Tissue necrosis or severe hypertension
- No cases of tissue necrosis or severe hypertension
- All adverse events dissipated spontaneously within 48 hours
Original publication
Adverse Events of Peripherally Administered Norepinephrine During Surgery: A Prospective Multicenter Study. Anesth Analg. Published 5 January 2024. doi:10.
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