Pediatric anesthesia & critical care
Age-Dependent Electroencephalogram Features in Infants Under Spinal Anesthesia Appear to Mirror Physiologic Sleep in the Developing Brain: A Prospective Observational Study
Authors' conclusion
This work illustrates 2 separate key age-dependent transitions in EEG dynamics during infant spinal anesthesia that may reflect the maturation of underlying brain circuits: (1) diminishing discontinuities with increasing gestational age and (2) the appearance of spindles with increasing postmenstrual age.
Study context
- Population
- Infants undergoing infraumbilical surgery under spinal anesthesia (median age 11.5 weeks postmenstrual age, range 38–65)
- Participants
- 34 infants
- Outcome
- EEG features (discontinuity, spindles) and their relationship with gestational, postmenstrual or chronological age
Main finding
As reported in the abstract
- Spindles (observed from about 49 weeks postmenstrual age) best described by postmenstrual age; more likely with increasing postmenstrual age
- P =.002
- EEG discontinuities best described by gestational age; more likely with decreasing gestational age
- P = .015
Observational data: associations, not effects.
Original publication
Age-Dependent Electroencephalogram Features in Infants Under Spinal Anesthesia Appear to Mirror Physiologic Sleep in the Developing Brain: A Prospective Observational Study. Anesth Analg. Published 7 March 2023. doi:10.
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