Age-related epidemiology and outcomes of sepsis in Japanese critical care units: a nationwide administrative claims database study
Main finding · In-hospital mortalityResult — go to the resultAdjusted odds ratio 4.75 95% CI 4.37–5.16Authors' conclusion
Sepsis in Japanese critical care units demonstrated substantial age-related differences in epidemiology, treatment, resource utilization, and outcomes.
Study context
- Population
- Patients with sepsis in Japanese critical care units, Diagnosis Procedure Combination database, fiscal years 2010–2019met sepsis criteria
- Participants
- 511,848 patients
- Exposure
- 10-year age groups
- Outcome
- In-hospital mortality by age
Methodological detailsnationwide administrative claims database
- Nationwide administrative claims database
Main finding
In-hospital mortality
Adjusted odds ratio
4.75
95% CI 4.37–5.16
By group
≥ 90 years
24.9%
≥ 90 years vs ≤ 29 years
aOR 4.75 (95% CI 4.37–5.16)
As reported in the abstract
Observational data: associations, not effects.
Further findings
- ICU mortality — ≥ 90 years
- 9.5%
- Discharge home — ≥ 90 years
- 29.4%
ICU mortality
- ICU mortality increased with age
Discharge home
- Proportion discharged home declined with age
Organ support (vasopressors, mechanical ventilation)
- Use of organ support inversely related to age
Original publication
Age-related epidemiology and outcomes of sepsis in Japanese critical care units: a nationwide administrative claims database study. J Intensive Care. Published 17 December 2025. doi:10.
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