Respiratory failure & ventilation
Association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation: a nationwide cohort study
Main findingResult — go to the resultRisk difference - 2.3% 95% CI - 4.4% to - 0.3%Authors' conclusion
In patients with ventilated pneumonia, early administration of mucoactive agents was associated with lower in-hospital mortality.
Study context
- Population
- Adults with primary diagnosis of pneumonia requiring invasive mechanical ventilation within 2 days of admission, ventilated ≥ 2 days, Japanese Diagnosis Procedure Combination database, April 2012–March 2023
- Participants
- 10,942 adults
- Exposure
- Early mucoactive agents vs none
- Mucoactive agentn = 2,246
- Controln = 8,696reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide inpatient database, propensity score overlap weighting
- Nationwide inpatient database
- Propensity score overlap weighting
Main finding
As reported in the abstract
Risk difference
- 2.3%
95% CI - 4.4% to - 0.3%
P = 0.028
By group
Observational data: associations, not effects.
Secondary outcomes
Ventilator-free days at 28 days
- Did not significantly differ between groups
Original publication
Association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation: a nationwide cohort study. J Intensive Care. Published 16 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →