Respiratory failure & ventilation
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study
Main findingResult — go to the resultOdds ratio 1.56 95% CI 0.80–3.06Authors' conclusion
In AE-IPF patients using mechanical ventilation, the treatment outcome was not significantly better for PMX combined with high-dose mPSL than for high-dose mPSL alone.
Study context
- Population
- Adults with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) receiving high-dose methylprednisolone (mPSL) and mechanical ventilation on admission, Japanese Diagnosis Procedure Combination database, 2010–2018
- Participants
- 5,616 adults
- Exposure
- PMX combined with high-dose mPSL vs high-dose mPSL alone
- PMXn = 199
- mPSL alonen = 5,417reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide database, stabilised inverse probability of treatment weighting (IPTW) using propensity scores
- Nationwide database
- Stabilised inverse probability of treatment weighting (IPTW) using propensity scores
Main finding
As reported in the abstract
Odds ratio
1.56
95% CI 0.80–3.06
P = 0.19
By group
PMX vs mPSL alone
OR 1.56 (95% CI 0.80–3.06); P = 0.19
Observational data: associations, not effects.
Secondary outcomes
14- and 28-day mortality and hospital LOS
- No significant difference between the two groups
Original publication
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study. J Intensive Care. Published 11 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →