Mortality of severe pneumonia treated with methylprednisolone versus hydrocortisone: a propensity-matched analysis
Main finding · In-hospital mortalityResult — go to the resultRisk difference 4.5% 95% CI −0.082 to 9.1Authors' conclusion
No significant difference in in-hospital mortality was observed between patients with severe pneumonia treated with methylprednisolone and those treated with hydrocortisone.
Study context
- Population
- Adults with severe pneumonia admitted to hospitals between April 2017 and March 2022, Japanese Diagnosis Procedure Combination inpatient database623 matched pairs analysed
- Participants
- 5,084 adults
- Exposure
- Hydrocortisone vs methylprednisolone
- Outcome
- In-hospital mortality
Methodological detailspropensity-score matched, nationwide inpatient database
- Propensity-score matched
- Nationwide inpatient database
Main finding
As reported in the abstract
Risk difference
4.5%
95% CI −0.082 to 9.1
P = 0.054
By group
Hydrocortisone vs Methylprednisolone
risk difference 4.5% (95% CI −0.082 to 9.1); P = 0.054
Observational data: associations, not effects.
Further findings
| Outcome | Hydrocortisone | Methylprednisolone | RD (95% CI) | P value | |
|---|---|---|---|---|---|
| In-hospital mortality, patients with shock (subgroup) | 44.7% | 30.1% | 14.6% (1.4–27.8) | P = 0.031 | |
| −2002040Difference (linear scale) |
Original publication
Mortality of severe pneumonia treated with methylprednisolone versus hydrocortisone: a propensity-matched analysis. J Intensive Care. Published 15 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →